A second half brace from Domenico Berardi gave Sassuolo a valuable point in their 2-2 draw against Udinese last Sunday as the Neroverdi sit in 15th place.
Genoa are level on points with them and are on the back of an impressive draw against Juventus, in which Albert Gudmundsson scored his sixth goal of the season.
Genoa have struggled to replicate their decent home form on the road and will face a side that has failed to win each of their five matches at the Mapei Stadium.