Luton once again went close to pulling off a shock result when they were narrowly beaten at Old Trafford before the international break.
Rob Edwards' side have since moved out of the Premier League's relegation zone, after Everton were deducted 10 points.
The Hatters should see this match as a real opportunity to pick up a first win in six matches.
Crystal Palace have now lost three of their last four league matches, after Everton took the spoils in an entertaining affair two weeks ago.
The Eagles, however, remain well away from danger, in 13th place, and will be looking to get back to winning ways here.