A 2-2 draw with Augsburg means RB Leipzig have won only one of their last six ahead of Tuesday's welcome of Real Madrid. The German side have won seven of their last nine home matches and beat Los Blancos the last time these two faced off at the Red Bull Arena.
Real Madrid head to Germany on Tuesday night on a five-game unbeaten run, winning four times in that period. Carlo Ancelotti oversaw a resounding 4-0 victory over Girona on Saturday to open up a five-point lead at the top of La Liga.
Even without Jude Bellingham and just one available centre-back, Real Madrid should secure a first leg advantage.